Four Cases of Anti-PM/Scl Antibody-positive Juvenile Overlap Syndrome with Features of Myositis and Systemic Sclerosis.
نویسندگان
چکیده
منابع مشابه
Anti-pm/scl antibodies in connective tissue disease: Clinical and biological assessment of 14 patients.
INTRODUCTION Anti-PM/Scl antibodies (Anti-PM/Scl) represent a rarely encountered type of antinuclear antibodies. They have mainly been reported in association with idiopathic inflammatory myositis - systemic sclerosis overlap syndromes (also called scleromyositis or sclerodermatomyositis) but also with polymyositis, dermatomyositis and systemic sclerosis without features of overlap syndromes. S...
متن کاملPM/Scl syndrome veers towards scleroderma and the Jo-1 syndrome towards systemic sclerosis with more prominent lung disease
RA-like and erosive) and fibrosing alveolitis (reviewed in [9]). One feature of the syndrome is said to be 'mechanic's hands' which consists of hyperkeratosis of the fingers associated with cracking and fissuring of the skin overlying the finger pulp. When it was definitively demonstrated that the Jo-1 antigen was histidyl-tRNA synthetase, other tRNA synthetases, including alanyland threonyl-tR...
متن کاملAnti-PM-Scl antibody in patients with systemic sclerosis.
OBJECTIVES To compare systemic sclerosis (SSc) patients with and without anti-PM-Scl antibody. METHODS We reviewed the medical records of 76 anti-PM-Scl antibody positive SSc patients and 2349 anti-PMScl negative SSc patients first evaluated during 1980-2004. Patients were included if they had a clinical diagnosis of SSc either alone or in overlap with another connective tissue disease. Anti-...
متن کاملAnti-PM/Scl antibodies are found in Japanese patients with various systemic autoimmune conditions besides myositis and scleroderma
INTRODUCTION Anti-PM/Scl antibodies are associated with polymyositis (PM)/systemic scleroderma (SSc) overlap syndromes and are also found in other systemic autoimmune diseases. Although anti-PM/Scl reactivity is found in 3-11% of PM or SSc patients and in approximately 25% of PM/SSc overlap patients, previous large studies of Japanese patients with scleroderma reported that anti-PM/Scl are not ...
متن کاملThe changing landscape of the clinical value of the PM/Scl autoantibody system
Autoantibodies to the polymyositis/scleroderma (PM/Scl) complex have been associated with systemic sclerosis and PM/Scl overlap syndrome. The report of Hanke and colleagues in a recent issue of Arthritis Research and Therapy is the first to describe the separate evaluation of anti-PM/Scl-75c and PM/Scl-100 autoantibodies and their relationship to clinical manifestations of systemic sclerosis. S...
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ورودعنوان ژورنال:
- The Journal of rheumatology
دوره 43 9 شماره
صفحات -
تاریخ انتشار 2016